Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
Identifieur interne : 000E08 ( Main/Exploration ); précédent : 000E07; suivant : 000E09Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
Auteurs : Boksik Cha [États-Unis] ; Xin Geng [États-Unis] ; Md. Riaj Mahamud [États-Unis] ; Jianxin Fu [États-Unis] ; Anish Mukherjee [États-Unis] ; Yeunhee Kim [États-Unis] ; Eek-Hoon Jho [Corée du Sud] ; Tae Hoon Kim [États-Unis] ; Mark L. Kahn [États-Unis] ; Lijun Xia [États-Unis] ; J. Brandon Dixon [États-Unis] ; Hong Chen [États-Unis] ; R. Sathish Srinivasan [États-Unis]Source :
- Genes & Development [ 0890-9369 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Cellules endothéliales (cytologie), Extinction de l'expression des gènes, Facteurs de transcription Forkhead (génétique), Facteurs de transcription Forkhead (métabolisme), Humains, Lymphangiogenèse (physiologie), Mécanotransduction cellulaire (physiologie), Régulation de l'expression des gènes au cours du développement, Souris, Vaisseaux lymphatiques (embryologie), Voie de signalisation Wnt (physiologie), bêta-Caténine (génétique), bêta-Caténine (métabolisme).
- MESH :
- cytologie : Cellules endothéliales.
- embryologie : Vaisseaux lymphatiques.
- génétique : Facteurs de transcription Forkhead, bêta-Caténine.
- métabolisme : Facteurs de transcription Forkhead, bêta-Caténine.
- physiologie : Lymphangiogenèse, Mécanotransduction cellulaire, Voie de signalisation Wnt.
- Animaux, Cellules cultivées, Extinction de l'expression des gènes, Humains, Régulation de l'expression des gènes au cours du développement, Souris.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Endothelial Cells (cytology), Forkhead Transcription Factors (genetics), Forkhead Transcription Factors (metabolism), Gene Expression Regulation, Developmental, Gene Silencing, Humans, Lymphangiogenesis (physiology), Lymphatic Vessels (embryology), Mechanotransduction, Cellular (physiology), Mice, Wnt Signaling Pathway (physiology), beta Catenin (genetics), beta Catenin (metabolism).
- MESH :
- chemical , genetics : Forkhead Transcription Factors, beta Catenin.
- cytology : Endothelial Cells.
- embryology : Lymphatic Vessels.
- chemical , metabolism : Forkhead Transcription Factors, beta Catenin.
- physiology : Lymphangiogenesis, Mechanotransduction, Cellular, Wnt Signaling Pathway.
- Animals, Cells, Cultured, Gene Expression Regulation, Developmental, Gene Silencing, Humans, Mice.
Abstract
In this study, Cha et al. show that the Wnt/β-catenin signaling pathway is the link between fluid flow and lymphatic vascular morphogenesis. They provide a molecular and structural framework to study mammalian lymphatic vasculature by demonstrating that mechanical stimulation is a critical regulator of lymphatic vascular development via activation of Wnt/β-catenin signaling.
Url:
DOI: 10.1101/gad.282400.116
PubMed: 27313318
PubMed Central: 4926867
Affiliations:
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Riaj" last="Mahamud">Md. Riaj Mahamud</name><affiliation wicri:level="1"><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><affiliation wicri:level="1"><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation></author><author><name sortKey="Mukherjee, Anish" sort="Mukherjee, Anish" uniqKey="Mukherjee A" first="Anish" last="Mukherjee">Anish Mukherjee</name><affiliation wicri:level="1"><nlm:aff id="af3">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332</wicri:regionArea><wicri:noRegion>Georgia 30332</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yeunhee" sort="Kim, Yeunhee" uniqKey="Kim Y" first="Yeunhee" last="Kim">Yeunhee Kim</name><affiliation wicri:level="1"><nlm:aff id="af4">Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080</wicri:regionArea><wicri:noRegion>Texas 75080</wicri:noRegion></affiliation></author><author><name sortKey="Jho, Eek Hoon" sort="Jho, Eek Hoon" uniqKey="Jho E" first="Eek-Hoon" last="Jho">Eek-Hoon Jho</name><affiliation wicri:level="1"><nlm:aff id="af5">Department of Life Science, University of Seoul, Seoul 130-743, Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Life Science, University of Seoul, Seoul 130-743</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Tae Hoon" sort="Kim, Tae Hoon" uniqKey="Kim T" first="Tae Hoon" last="Kim">Tae Hoon Kim</name><affiliation wicri:level="1"><nlm:aff id="af4">Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080</wicri:regionArea><wicri:noRegion>Texas 75080</wicri:noRegion></affiliation></author><author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><affiliation wicri:level="1"><nlm:aff id="af6">Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation wicri:level="1"><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af7">Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><affiliation wicri:level="1"><nlm:aff id="af3">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332</wicri:regionArea><wicri:noRegion>Georgia 30332</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="1"><nlm:aff id="af8">Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><affiliation wicri:level="1"><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104</wicri:regionArea><wicri:noRegion>Oklahoma 73104</wicri:noRegion></affiliation></author></analytic><series><title level="j">Genes & Development</title><idno type="ISSN">0890-9369</idno><idno type="eISSN">1549-5477</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Endothelial Cells (cytology)</term><term>Forkhead Transcription Factors (genetics)</term><term>Forkhead Transcription Factors (metabolism)</term><term>Gene Expression Regulation, Developmental</term><term>Gene Silencing</term><term>Humans</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic Vessels (embryology)</term><term>Mechanotransduction, Cellular (physiology)</term><term>Mice</term><term>Wnt Signaling Pathway (physiology)</term><term>beta Catenin (genetics)</term><term>beta Catenin (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules endothéliales (cytologie)</term><term>Extinction de l'expression des gènes</term><term>Facteurs de transcription Forkhead (génétique)</term><term>Facteurs de transcription Forkhead (métabolisme)</term><term>Humains</term><term>Lymphangiogenèse (physiologie)</term><term>Mécanotransduction cellulaire (physiologie)</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Souris</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Voie de signalisation Wnt (physiologie)</term><term>bêta-Caténine (génétique)</term><term>bêta-Caténine (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Forkhead Transcription Factors</term><term>beta Catenin</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription Forkhead</term><term>bêta-Caténine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Forkhead Transcription Factors</term><term>beta Catenin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription Forkhead</term><term>bêta-Caténine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Mécanotransduction cellulaire</term><term>Voie de signalisation Wnt</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Mechanotransduction, Cellular</term><term>Wnt Signaling Pathway</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Gene Expression Regulation, Developmental</term><term>Gene Silencing</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Extinction de l'expression des gènes</term><term>Humains</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, Cha et al. show that the Wnt/β-catenin signaling pathway is the link between fluid flow and lymphatic vascular morphogenesis. They provide a molecular and structural framework to study mammalian lymphatic vasculature by demonstrating that mechanical stimulation is a critical regulator of lymphatic vascular development via activation of Wnt/β-catenin signaling.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Cha, Boksik" sort="Cha, Boksik" uniqKey="Cha B" first="Boksik" last="Cha">Boksik Cha</name></noRegion><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><name sortKey="Geng, Xin" sort="Geng, Xin" uniqKey="Geng X" first="Xin" last="Geng">Xin Geng</name><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><name sortKey="Kim, Tae Hoon" sort="Kim, Tae Hoon" uniqKey="Kim T" first="Tae Hoon" last="Kim">Tae Hoon Kim</name><name sortKey="Kim, Yeunhee" sort="Kim, Yeunhee" uniqKey="Kim Y" first="Yeunhee" last="Kim">Yeunhee Kim</name><name sortKey="Mahamud, Md Riaj" sort="Mahamud, Md Riaj" uniqKey="Mahamud M" first="Md. Riaj" last="Mahamud">Md. Riaj Mahamud</name><name sortKey="Mahamud, Md Riaj" sort="Mahamud, Md Riaj" uniqKey="Mahamud M" first="Md. Riaj" last="Mahamud">Md. Riaj Mahamud</name><name sortKey="Mukherjee, Anish" sort="Mukherjee, Anish" uniqKey="Mukherjee A" first="Anish" last="Mukherjee">Anish Mukherjee</name><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Jho, Eek Hoon" sort="Jho, Eek Hoon" uniqKey="Jho E" first="Eek-Hoon" last="Jho">Eek-Hoon Jho</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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